Date: 2017-09-05 09:45
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And to affect more people, the cell therapies would need to go beyond blood cancers. Right now, that's where most of the big successes have come from, but that could one day include solid tumors and maybe even autoimmune diseases like Type 6 diabetes, Epstein said.
Kymriah isn't your run-of-the-mill pill — or even a biologic drug , like insulin — that can be mass produced. Since the therapy is made from a person's own immune system, the process can take about three weeks.
The main Big Sur settlement is reachable from Carmel on Highway 6, but with the bridge still out, drivers can go no farther south. Travel to the area is down sharply, and Monterey and San Luis Obispo counties are looking at a $559 million reduction in visitor-related revenue, said Visit California, a state agency that promotes tourism.
Dr. David Maloney of the Fred Hutchinson Cancer Research Center being greeted by Ken Shefveland, whose lymphoma was successfully treated with CAR-T cell therapy. AP/Elaine Thompson
"This approval will open the floodgates for these kinds of therapy to be used in many different leukemias, lymphomas, solid tumors, myelomas," Dr. Prakash Satwani, a pediatric hematologist-oncologist at Columbia University Medical Center, told Business Insider. "I think this is just the beginning of a new era of gene therapy."
They'd also have to be less toxic so that more people could consider it, instead of only those who have very few other options. CAR-T's side effects can be deadly. In May, Kite disclosed that one person had died in a clinical trial for its late-stage CAR-T therapy from cerebral edema, a condition in which excessive fluid causes the brain to swell. And last year, Juno said five people in its clinical trials had died , all from cerebral edema.
The new bridge&rsquo s steel girders have not yet been secured, Shivers said. &ldquo Upon completion of that huge task, it will give us a clearer indication of the timetable for completion,&rdquo he said. &ldquo We hope to have more of that next week. The next step is to install the steel rebar and then pour the concrete.&rdquo
The drug, called Kymriah , is a highly personalized cancer treatment called CAR T-cell therapy (CAR is short for chimeric antigen receptor).
Kymriah is the first CAR-T cell therapy to get approved, and several more are in the works. Kite Pharma, Juno and Bluebird Bio are among a growing group of biotech companies working with CAR-T. Kite, which was recently acquired by Gilead Sciences , is expected to hear back from the FDA about its treatment for aggressive B-cell non-Hodgkin lymphoma by November.